LexOWL: A Bridge from LexGrid to OWL

The Lexical Grid project is an on-going community driven initiative that provides a common terminology model to represent multiple vocabulary and ontology sources as well as a scalable and robust API for accessing such information. In order to add more powerful functionalities to the existing infrastructure and align LexGrid more closely with various Semantic Web technologies, we introduce the LexOWL project for representing the ontologies modeled within the LexGrid environment in OWL (Web Ontology Language). The crux of this effort is to create a “bridge” that functionally connects the LexBIG (a LexGrid API) and the OWL API (an interface that implements OWL) seamlessly. In this paper, we discuss the key aspects of designing and implementing the LexOWL bridge. We compared LexOWL with other OWL converting tools and conclude that LexOWL provides an OWL mapping and converting tool with well-defined interoperability for information in the biomedical domain

LexOWL: A Bridge from LexGrid to OWL

The Lexical Grid project is an on-going community driven initiative that provides a common terminology model to represent multiple vocabulary and ontology sources as well as a scalable and robust API for accessing such information. In order to add more powerful functionalities to the existing infrastructure and align LexGrid more closely with various Semantic Web technologies, we introduce the LexOWL project for representing the ontologies modeled within the LexGrid environment in OWL (Web Ontology Language). The crux of this effort is to create a “bridge” that functionally connects the LexBIG (a LexGrid API) and the OWL API (an interface that implements OWL) seamlessly. In this paper, we discuss the key aspects of designing and implementing the LexOWL bridge. We compared LexOWL with other OWL converting tools and conclude that LexOWL provides an OWL mapping and converting tool with well-defined interoperability for information in the biomedical domain

Complexity and Expressiveness of ShEx for RDF

International audienceWe study the expressiveness and complexity of Shape Expression Schema (ShEx), a novel schema formalism for RDF currently under development by W3C. ShEx assigns types to the nodes of an RDF graph and allows to constrain the admissible neighborhoods of nodes of a given type with regular bag expressions (RBEs). We formalize and investigate two alternative semantics, multi-and single-type, depending on whether or not a node may have more than one type. We study the expressive power of ShEx and study the complexity of the validation problem. We show that the single-type semantics is strictly more expressive than the multi-type semantics, single-type validation is generally intractable and multi-type validation is feasible for a small (yet practical) subclass of RBEs. To curb the high computational complexity of validation, we propose a natural notion of determinism and show that multi-type validation for the class of deterministic schemas using single-occurrence regular bag expressions (SORBEs) is tractable

Clinical Data: Sources and Types, Regulatory Constraints, Applications.

Access to clinical data is critical for the advancement of translational research. However, the numerous regulations and policies that surround the use of clinical data, although critical to ensure patient privacy and protect against misuse, often present challenges to data access and sharing. In this article, we provide an overview of clinical data types and associated regulatory constraints and inferential limitations. We highlight several novel approaches that our team has developed for openly exposing clinical data

The National COVID Cohort Collaborative (N3C): Rationale, design, infrastructure, and deployment.

OBJECTIVE: Coronavirus disease 2019 (COVID-19) poses societal challenges that require expeditious data and knowledge sharing. Though organizational clinical data are abundant, these are largely inaccessible to outside researchers. Statistical, machine learning, and causal analyses are most successful with large-scale data beyond what is available in any given organization. Here, we introduce the National COVID Cohort Collaborative (N3C), an open science community focused on analyzing patient-level data from many centers. MATERIALS AND METHODS: The Clinical and Translational Science Award Program and scientific community created N3C to overcome technical, regulatory, policy, and governance barriers to sharing and harmonizing individual-level clinical data. We developed solutions to extract, aggregate, and harmonize data across organizations and data models, and created a secure data enclave to enable efficient, transparent, and reproducible collaborative analytics. RESULTS: Organized in inclusive workstreams, we created legal agreements and governance for organizations and researchers; data extraction scripts to identify and ingest positive, negative, and possible COVID-19 cases; a data quality assurance and harmonization pipeline to create a single harmonized dataset; population of the secure data enclave with data, machine learning, and statistical analytics tools; dissemination mechanisms; and a synthetic data pilot to democratize data access. CONCLUSIONS: The N3C has demonstrated that a multisite collaborative learning health network can overcome barriers to rapidly build a scalable infrastructure incorporating multiorganizational clinical data for COVID-19 analytics. We expect this effort to save lives by enabling rapid collaboration among clinicians, researchers, and data scientists to identify treatments and specialized care and thereby reduce the immediate and long-term impacts of COVID-19